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What's New in Martindale: The Complete Drug Reference
Volume 129

21 New Monographs

Abatacept - Abatacept, a fusion protein, is a co-stimulation blocker that prevents T-cell activation and is used in the treatment of rheumatoid arthritis. It is also being studied for other auto-immune diseases such as multiple sclerosis, psoriasis, and SLE.

Alitame - Alitame is an intense sweetener used in foods.

Bisoctrizole - Bisoctrizole is used as a sunscreen. It is effective against UVA light.

Carnitine Derivatives including Levocarnitine Hydrochloride, Levocarnitine Propionate, and Levocarnitine Propionate Hydrochloride - Carnitine is an amino acid derivative that is an essential cofactor of fatty acid metabolism. It is used as levocarnitine in the treatment of primary carnitine deficiency and in the management of carnitine deficiency secondary to a variety of defects of intermediary metabolism or to haemodialysis. Carnitine derivatives have been used to treat conditions including cardiovascular disease, peripheral arterial disease, cerebrovascular insufficiency, peripheral neuropathies, and neurological disorders.

Cobamamide and Mecobalamin - Cobamamide and mecobalamin are cobalamins and have the actions and uses of vitamin B12.

Cocarboxylase - Cocarboxylase is a form of thiamine and has the actions and uses of vitamin B1.

Cystitis - Treatment review

Daidzein - Daidzein is a soya isoflavone. Soya isoflavones have been investigated for their potential role in the treatment of hyperlipidaemia, menopausal symptoms, osteoporosis, and cancer. Daidzein is a component of some herbal medicines traditionally used in the management of alcohol abuse.

Haemorrhagic cystitis - Treatment review

Ivabradine - Ivabradine is a selective sinus node If inhibitor that is used in angina pectoris.

Ivy Leaf - Ivy leaf is a herbal medicine used for catarrh and chronic inflammation of the respiratory tract. Hedera helix is used in homoeopathic medicine.

Kinetin - Kinetin is a plant growth hormone that has been promoted in products for the management of photodamaged skin and hyperpigmentation.

Liarozole - Liarozole is an inhibitor of cytochrome P450 isoenzymes involved in retinoic acid catabolism. It is under investigation for the management of ichthyoses and psoriasis.

Lutein - Lutein is a naturally occurring carotenoid that has been investigated for its role in a number of conditions including age-related macular degeneration, cataracts, cardiovascular disease, and cancer.

5,10-Methylenetetrahydrofolate - 5,10-Methylenetetrahydrofolate is an active metabolite of folinic acid. It is under investigation for use with fluorouracil in the treatment of pancreatic cancer and metastatic colorectal cancer.

Neohesperidin Dihydrochalcone - Neohesperidin dihydrochalcone is an intense sweetener derived from naringin present in citrus peel.

Oxapium Iodide - Oxapium iodide is an antimuscarinic that has been used as an antispasmodic in the treatment of gastrointestinal disorders and renal calculi.

Premature ejaculation - Treatment review.

Rotigotine - Rotigotine is a non-ergot dopamine D2-agonist that is being studied as a transdermal preparation in the treatment of Parkinson's disease and restless legs syndrome.

Setiptiline - Setiptiline is an antidepressant.

Zeaxanthin - Zeaxanthin is a naturally occurring carotenoid that is used as a dietary supplement for age-related macular degeneration.

6 Revised Chapters or Chapter Sections - content systematically re-validated and updated

- Antidementia Drugs
- Antidepressants
- Antimyasthenics
- Antiparkinsonian Drugs
- Cardiovascular Drugs - Introduction
- Gastrointestinal Drugs - Aminosalicylates
- Gastrointestinal Drugs - Antacids
- Gastrointestinal Drugs - Antidiarrhoeals
- Gastrointestinal Drugs - Antiemetics
- Gastrointestinal Drugs - Antispasmodics
- Nutritional Agents and Vitamins
- Urological Drugs

Selective Updates - New or changed information

  • Alefacept
  • Alglucerase
  • Alpha-proteinase Inhibitor
  • Anagrelide Hydrochloride
  • Arsenic Trioxide
  • Benazepril Hydrochloride
  • Cachexia
  • Cefodizime
  • Diltiazem Hydrochloride
  • Dipyridamole
  • Eplrenone
  • Ergometrine Maleate
  • Flecainide Acetate
  • Flutamide
  • Gynaecomastia
  • Laronidase
  • Malignant Neoplasms of the GI Tract
  • Mastocytosis
  • Melagatran
  • Mexiletine Hydrochloride
  • Mycophenolate Mofetil
  • Nifedipine
  • Omega-3 Triglycerides
  • Pegaptinib Sodium
  • Perindopril
  • Pimecrolimus
  • Rheumatoid Arthritis
  • Riluzole
  • Somatomedins
  • Testosterone
  • Ziconotide
    ...and minor changes to 42 other documents

New Proprietary Preparations

- Australia *
- Chile
- France *
- Greece
- Spain
- United Kingdom*
- United States *
- Venezuela (new country)

( * = Countries updated on an ongoing basis )


The electronic version also contains quarterly data revisions since publication of the 34th Edition of Martindale:

New proprietary information for:

- Argentina
- Australia
- Brazil
- Canada
- France
- Hong Kong
- India
- Ireland
- Japan
- Malaysia
- Mexico
- New Zealand
- Portugal
- Russia
- Singapore
- South Africa
- Spain
- United Kingdom
- United States

Revised chapters

- Anticoagulants
- Antifungals
- Anxiolytic Sedatives Hypnotics and Antipsychotics - Introduction
- Blood Products Plasma Expanders and Haemostatics
- Bone Modulating drugs
- Cardiovascular Drugs - Miscellaneous Antihypertensives
- Cardiovascular Drugs - Sympathomimetics
- Chelators Antidotes and Antagonists
- Hypothalamic and Pituitary Hormones

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New monographs

- Aclatonium napadisilate
- Acquired Haemorrhagic Disorders
- Aliskiren
- Ammonium Glycyrrhizinate
- Anecortave
- Aplidine
- Argipressin
- Ash
- Asoprisnil
- AST-120
- Atrasentan hydrochloride
- Becatecarin
- Bepotastine Besilate
- Bicifadine Hydrochloride
- Bifendate
- Brivaracetam
- Butcher's Broom
- Calcium Propionate
- Cannabidiol
- Cellaburate
- Cilengitide
- Conivaptan hydrochloride
- Deferasirox
- Doripenem
- Efaproxiral and Efaproxiral Sodium
- Entecavir
- Erlotinib hydrochloride
- Eszopiclone
- Exenatide
- Extrapyramidal Disorders
- Factor XI
- Febuxostat
- Forodesine Hydrochloride
- Fosfluconazole
- Galsulfase
- Glucarpidase
- Haemophilias
- Hexaminolevulinate Hydrochloride
- ICA-17043
- Indisetron Hydrochloride
- Inherited Haemorrhagic Disorders
- Lubiprostone
- Mecasermin
- Melengestrol Acetate
- Melilot
- Mepolizumab
- Minodronate and Minodronic Acid
- Mitiglinide
- Muraglitazar
- Nelarabine
- Nifurpirinol
- Nimotuzumab
- Olpadronate, Olpadronate Disodium and Olpadronic Acid
- Palifermin
- Pegaptanib
- Pixantrone
- Pralmorelin
- Pronase
- Ramelteon
- Rasagiline Mesilate
- Ravuconazole
- Resocortol Butyrate
- Rimonabant
- Ruboxistaurin
- Schisandra
- Semaxanib
- Siccanin
- Sitaxentan
- Sodium edetate
- Suberoylanilide Hydroxamic Acid
- Sulfaphenazole
- Sulfathiazole silver
- Sympathomimetics
- Temsirolimus
- Tetrahydrogestrinone
- Thrombocytopenia
- Tigecycline
- Tretamine
- Trimedoxime bromide
- Vildagliptin
- von Willebrand factor
- Zinc Trisodium Pentetate

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Selective updates - new or changed information

- Abciximab
- Acamprosate
- Acute Respiratory Distress Syndrome
- Agnus Castus
- Alendronate
- Alitretinoin
- Alosetron Hydrochloride
- Alpha Galactosidase A
- Alprazolam
- Amiodarone
- Anagrelide Hydrochloride
- Anakinra
- Antineoplastics (Treatment of adverse effects)
- Anxiety Disorders
- Aplidine
- Aprepitant
- Aprepitant
- Asthma
- Atomoxetine
- Atomoxetine Hydrochloride
- Atropine Sulfate
- Azithromycin
- Azithromycin
- Beclometasone Dipropionate
- Beta blockers
- Bevacizumab
- Blood
- Bone Morphogenetic Proteins
- Borax
- Bortezomib
- Botulinum Toxins
- Brimonidine Tartrate
- Brivudine
- Bromfenac Sodium
- Bromocriptine Mesilate
- Bronchopulmonary Dysplasia
- Bronchopulmonary Dysplasia
- Buchu
- Budesonide
- Budesonide
- Busulfan
- Calcitonins
- Calcium Carbonate
- Candesartan
- Cannabis
- Carmustine
- Caroverine
- Cefditoren Pivoxil
- Celecoxib
- Celecoxib
- Cetirizine Hydrochloride
- Cetuximab
- Cetuximab
- Chloroquine
- Chronic Obstructive Pulmonary Disease
- Ciclesonide
- Ciclosporin
- Ciclosporin
- Cimicifuga
- Cisapride
- Clenbuterol Hydrochloride
- Clofarabine
- Clomifene Citrate
- Clomifene Citrate
- Clonazepam
- Clopidogrel
- Clorazepate Monopotassium
- Clozapine
- Colchicine
- Constipation
- Corticosteroids
- Co-trimoxazole
- Cyclophosphamide
- Cytomegalovirus Infections
- Dapsone
- Darifenacin
- Dexamethasone
- Dexamfetamine Sulfate
- Dexibruprofen
- Dexibuprofen
- Dextropropoxyphene
- Dextropropoxyphene
- Diabetes Mellitus
- Diabetic Complications
- Diarrhoea
- Diffuse Parenchymal Lung Disease
- Docetaxel
- Docusates
- Dofetilide
- Doxorubicin
- Drospirenone
- Duloxetine Hydrochloride
- Dyspepsia
- Echinacea
- Efalizumab
- Eflornithine Hydrochloride
- Emtricitabine
- Ephedra
- Epilepsy
- Epilepsy and Breast Feeding
- Epilepsy and Cognition
- Epilepsy and Pregnancy
- Ertapenem Sodium
- Esomeprozole Magesium
- Etanercept
- Etanercept
- Etanercept
- Etoricoxib
- Everolimus
- Everolimus
- Exemestane
- Exenatide
- Ezetimibe
- Famotidine
- Fentanyl
- Fentanyl
- Flucloxacillin
- Fludarabine Phosphate
- Fluorouracil
- Fluoxetine Hydrochloride
- Fluticasone Propionate
- Formoterol Fumarate
- Fosamprenavir Calcium
- Galantamine
- Galantamine Hydrobromide
- Gastro-oesophageal Reflux Disease
- Gatifloxacin
- Gefitinib
- Glyceryl Trintrate
- Heparin
- Herpes simplex infections
- HIV Infection Prophylaxis
- HIV-associated infections
- Hormonal Contraceptives
- Hydromorphone Hydrochloride
- Hydromorphone Hydrochloride
- Hypercalcaemia of Malignancy
- Hypericum (title changed to St John's Wort)
- Ibandronate
- Idebenone
- Imiquimod
- infections in Immunocompromised patients
- Inflammatory Bowel Disease
- Inflammatory Bowel Disease
- Infliximab
- Infliximab
- Insulin
- Insulin
- Interleukin-2
- Irbesartan
- Ivermectin
- Ketotifen Fumarate
- Kidney Transplantation
- Lamotrigine
- Lamotrigine
- Lansoprazole
- Lead
- Leflunomide
- Legionnaires' Disease
- Leprosy
- Lerdelimumab
- Levetiracetam
- Levofloxacin
- Levofloxacin
- Lidocaine
- Linezolid
- Linezolid
- Loperamide Hydrochloride
- Losartan
- Magnesium
- Malignant Neoplasms of the Breast
- Malignant Neoplasms of the prostate
- Mastalgia
- Medication-overuse Headache
- Medroxyprogesterone Acetate
- Mefloquine Hydrochloride
- Megestrol Acetate
- Mercaptopurine
- Metformin Hydrochloride
- Metformin Hydrochloride
- Methylphenidate
- Microscopic colitis (formerly Collagenous colitis)
- Mifepristone
- Migraine
- Miltefosine
- Mometasone Furoate
- Moxifloxacin Hydrochloride
- Muscular Dystrophies
- Mycophenolate Mofetil
- Nandrolone
- Natalizumab
- Nausea and Vomiting
- Nefazodone Hydrochloride
- Nesiritide Citrate
- Nifekalant
- Nitazoxanide
- Nitazoxanide
- Nitazoxanide
- Nitisinone
- Norgestrel
- NSAIDs
- Obsessive-compulsive Disorder
- Olanzapine
- Olmesartan Medoxomil
- Omeprazole
- Omeprazole
- Omeprazole
- Ondansetron
- Opioid Analgesics
- Opportunistic Mycobacterial infections
- Oral Rehydration Solutions
- Oseltamivir
- Oxaliplatin
- Oxandrolone
- Oxcarbazepine
- Paclitaxel
- Palonosetron Hydrochloride
- Pancreatitis
- Panic attacks
- Pantoprazole
- Pantoprazole
- Parecoxib Sodium
- Pemetrexed Disodium
- Peptic Ulcer Disease
- Pergolide Mesilate
- Permethrin
- Phosphate
- Phosphatidyl Choline
- Pimecrolimus
- Pioglitazone Hydrochloride
- Pioglitazone Hydrochloride
- Piperaquine Phosphate
- Postoperative Analgesia
- Pramlintide
- Prasterone
- Pregabalin
- Pregabalin
- Promethazine
- Propafenone
- Prulifloxacin
- Pseudoephedrine
- Quinapril Hydrochloride
- Ramoplanin
- Ramosetron Hydrochloride
- Rasagiline Mesilate
- Repaglinide
- Repaglinide
- Risedronate
- Rituximab
- Rofecoxib
- Roflumilast
- Rosiglitazone Maleate
- Royal Jelly
- Salbutamol
- Sapropterin Hydrochloride
- Scabies
- Senna
- Sirolimus
- Spinal Cord Injury
- Spinal Cord Injury
- Status epilepticus
- Streptomycin
- Sulfonylurea Antidiabetics
- Sumatriptan
- Tacrolimus
- Tamoxifen Citrate
- Tamoxifen Citrate
- Telithromycin
- Telithromycin
- Telmisartan
- Temoporfin
- Tenofovir
- Terbinafine
- Testosterone
- Thioridazine
- Tiagabine
- Tibolone
- Ticlopidine Hydrochloride
- Tioguanine
- Tiotropium Bromide
- Tiropramide Hydrochloride
- Tizanidine Hydrochloride
- Tocilizumab
- Tolcapone
- Topiramate
- Topiramate
- Tositumomab
- Toxoplasmosis
- Treprostinil
- Triamcinolone
- Trimetazidine
- Tryptophan
- Valdecoxib
- Valsartan
- Verapamil Hydrochloride
- Voriconazole
- Warfarin sodium
- Ziconotide
- Zoledronate
- Zoledronate
- Zonisamide

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